Monoclonal antibody targeting of fibroblast growth factor receptor 1c ameliorates obesity and glucose intolerance via central mechanisms.

We have generated a novel monoclonal antibody targeting human FGFR1c (R1c mAb) that caused profound body weight and body fat loss in diet-induced obese mice due to decreased food intake (with energy expenditure unaltered), in turn improving glucose control.R1c mAb also caused weight loss in leptin-deficient ob/ob mice, leptin receptor-mutant db/db

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Frequency of pathology in a large natural sample from Natural Trap Cave with special remarks on erosive disease in the Pleistocene

The search for the Figurines antiquity of erosive arthritis was the subject of an international conference (1).Although isolated examples have been reported from the anthropologic record (2, 3), systemic population studies have represented a newer approach (4).Recognition of erosive disease, osteoarthritis and DISH, as isolated Tripod Stand observa

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